Florence
Florence, Tuscany's capital, birthplace of the Renaissance. The Duomo (Brunelleschi's Dome), Palazzo Vecchio, Uffizi, and Ponte Vecchio over the Arno are tightly grouped. Michelangelo's David is in the Galleria dell'Accademia. Across the river, Oltrarno features Palazzo Pitti, the Boboli Gardens, and artisan workshops. A UNESCO World Heritage site since 1982, the Old Town is easily explored on foot. Florence is roughly 1.5 hours from Rome by high-speed train. You should reserve tickets for Uffizi, Accademia, and Duomo Dome in advance.